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Neurology. 2013 May 21;80(21):1973-7. doi: 10.1212/WNL.0b013e318293e368. Epub 2013 May 1.

Interrater reliability of the new criteria for behavioral variant frontotemporal dementia.

Author information

1
Memory and Aging Center, Department of Neurology, University of California San Francisco, USA. LaMarreA@radonc.ucsf.edu

Abstract

OBJECTIVE:

To evaluate the interrater reliability of the new International Behavioural Variant FTD Criteria Consortium (FTDC) criteria for behavioral variant frontotemporal dementia (bvFTD).

METHODS:

Twenty standardized clinical case modules were developed for patients with a range of neurodegenerative diagnoses, including bvFTD, primary progressive aphasia (nonfluent, semantic, and logopenic variant), Alzheimer disease, and Lewy body dementia. Eighteen blinded raters reviewed the modules and 1) rated the presence or absence of core diagnostic features for the FTDC criteria, and 2) provided an overall diagnostic rating. Interrater reliability was determined by κ statistics for multiple raters with categorical ratings.

RESULTS:

The mean κ value for diagnostic agreement was 0.81 for possible bvFTD and 0.82 for probable bvFTD ("almost perfect agreement"). Interrater reliability for 4 of the 6 core features had "substantial" agreement (behavioral disinhibition, perseverative/compulsive, sympathy/empathy, hyperorality; κ = 0.61-0.80), whereas 2 had "moderate" agreement (apathy/inertia, neuropsychological; κ = 0.41-0.6). Clinician years of experience did not significantly influence rater accuracy.

CONCLUSIONS:

The FTDC criteria show promise for improving the diagnostic accuracy and reliability of clinicians and researchers. As disease-altering therapies are developed, accurate differential diagnosis between bvFTD and other neurodegenerative diseases will become increasingly important.

PMID:
23635967
PMCID:
PMC3716343
DOI:
10.1212/WNL.0b013e318293e368
[Indexed for MEDLINE]
Free PMC Article
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