Format

Send to

Choose Destination
RNA Biol. 2013;10(9):1433-8. doi: 10.4161/rna.24770. Epub 2013 Apr 23.

Human pentatricopeptide proteins: only a few and what do they do?

Author information

1
The Wellcome Trust Centre for Mitochondrial Research; Institute for Cell and Molecular Biosciences; Newcastle University; The Medical School; Framlington Place; Newcastle upon Tyne, UK.
2
The Wellcome Trust Centre for Mitochondrial Research; Institute for Ageing and Health; Newcastle University; The Medical School; Framlington Place; Newcastle upon Tyne, UK.

Abstract

Pentatricopeptide repeat (PPR) proteins constitute a large family of RNA-binding proteins that contain a canonical 35 residue repeat motif. Originally identified in Arabidopsis thaliana, family members are found in protists, fungi, and metazoan but are by far most abundant in plant organelles. Seven examples have been identified in human mitochondria and roles have been tentatively ascribed to each. In this review, we briefly outline each of these PPR proteins and discuss the role each is believed to play in facilitating mitochondrial gene expression.

KEYWORDS:

Pentatricopeptide; RNA binding; human; mitochondria; post-transcriptional gene expression; translation

PMID:
23635806
PMCID:
PMC3858426
DOI:
10.4161/rna.24770
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Taylor & Francis Icon for PubMed Central
Loading ...
Support Center