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Hepatogastroenterology. 2013 May;60(123):461-5.

The prevalence and risk factors of gallstones in Korean patients with liver cirrhosis.

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1
Division of Gastroenterology, Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, Korea.

Abstract

BACKGROUND/AIMS:

The aims of this study were to evaluate the frequency of gallstones and the related risk factors in patients with liver cirrhosis.

METHODOLOGY:

Patients (n=1,333) with liver cirrhosis who were diagnosed at Yeungnam University Hospital between January 2006 and December 2008 were analyzed retrospectively. Healthy people (n=16,922) who underwent an examination at the health promotion center were enrolled as a control group. We analyzed the clinical and laboratory findings between the cirrhotic patients with and without gallstones.

RESULTS:

Liver cirrhosis was an independent risk factor for gallstone formation (OR: 2.017; p=0.00). Diabetes and hypertriglyceridemia increased the risk for gallstones by 2.2-fold and 1.9-fold in cirrhotic patents, respectively. The severity of the liver cirrhosis according to the Child-Pugh class carried a significantly greater risk of gallstone formation. Multiple logistic regression analysis showed that diabetes, hypertriglyceridemia, and Child-Pugh class C were significantly related to the risk of gallstone formation in patients with liver cirrhosis.

CONCLUSIONS:

The prevalence of gallstones is significantly higher in patients with liver cirrhosis, and the related risk factors are diabetes, hypertriglyceridemia and severity of liver cirrhosis.

PMID:
23635439
DOI:
10.5754/hge11950
[Indexed for MEDLINE]
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