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Neurosurg Focus. 2013 May;34(5):E7. doi: 10.3171/2013.2.FOCUS1323.

Dabigatran, intracranial hemorrhage, and the neurosurgeon.

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1
Faculty of Medicine and Health Sciences, An-Najah National University, Nablus, West Bank, Palestine.

Abstract

Dabigatran etexilate (Pradaxa) is a novel oral anticoagulant that has gained FDA approval for the prevention of ischemic stroke and systemic embolism in patients with nonvalvular atrial fibrillation. In randomized trials, the incidence of hemorrhagic events has been demonstrated to be lower in patients treated with dabigatran compared with the traditional anticoagulant warfarin. However, dabigatran does not have reliable laboratory tests to measure levels of anticoagulation and there is no pharmacological antidote. These drawbacks are challenging in the setting of intracerebral hemorrhage. In this article, the authors provide background information on dabigatran, review the existing anecdotal experiences with treating intracerebral hemorrhage related to dabigatran therapy, present a case study of intracranial hemorrhage in a patient being treated with dabigatran, and suggest clinical management strategies. The development of reversal agents is urgently needed given the growing number of patients treated with this medication.

PMID:
23634926
DOI:
10.3171/2013.2.FOCUS1323
[Indexed for MEDLINE]
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