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Nano Lett. 2013 Jun 12;13(6):2528-34. doi: 10.1021/nl400586t. Epub 2013 May 6.

Functionalized nanoscale micelles improve drug delivery for cancer therapy in vitro and in vivo.

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1
Chinese Academy of Sciences (CAS) Key Laboratory for Biological Effects of Nanomaterials and Nanosafety, National Center for Nanoscience and Technology, No. 11, First North Road, Zhongguancun, Beijing, China 100190.

Abstract

Poor penetration of therapeutic drugs into tumors is a major challenge in anticancer therapy, especially in solid tumors, leading to reduced therapeutic efficacy in vivo. In the study, we used a new tumor-penetrating peptide, CRGDK, to conjugate onto the surface of doxorubicin encapsulated nanoscale micelles. The CRGDK peptide triggered specific binding to neuropilin-1, leading to enhanced cellular uptake and cytotoxicity in vitro and highly accumulation and penetration in the tumors in vivo.

PMID:
23634882
DOI:
10.1021/nl400586t
[Indexed for MEDLINE]
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