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Acta Crystallogr D Biol Crystallogr. 2013 May;69(Pt 5):710-21. doi: 10.1107/S0907444913001157. Epub 2013 Apr 19.

The role of structural bioinformatics resources in the era of integrative structural biology.

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Protein Data Bank in Europe, EMBL-EBI, Wellcome Trust Genome Campus, Hinxton, Cambridge CB10 1SD, England.


The history and the current state of the PDB and EMDB archives is briefly described, as well as some of the challenges that they face. It seems natural that the role of structural biology archives will change from being a pure repository of historic data into becoming an indispensable resource for the wider biomedical community. As part of this transformation, it will be necessary to validate the biomacromolecular structure data and ensure the highest possible quality for the archive holdings, to combine structural data from different spatial scales into a unified resource and to integrate structural data with functional, genetic and taxonomic data as well as other information available in bioinformatics resources. Some recent developments and plans to address these challenges at PDBe are presented.


PDBe; integrative structural biology; structural bioinformatics

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