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Kidney Int. 2013 May;83(5):779-82. doi: 10.1038/ki.2012.468.

Need to quickly excrete K(+)? Turn off NCC.

Author information

1
Department of Cell and Neurobiology, Keck School of Medicine of the University of Southern California, Los Angeles, California, USA. mcdonoug@usc.edu

Abstract

Renal K(+) excretion is increased rapidly following dietary K(+) intake, but the underlying molecular mechanisms are largely unknown. Sorensen and colleagues show that K(+) intake in mice provoked rapid and near-complete dephosphorylation of the renal distal convoluted tubule NaCl cotransporter, temporally associated with increases in both Na(+) and K(+) excretion. This response was independent of aldosterone and may be a crucial component of the acute homeostatic adaptation of the kidney to K(+) intake.

PMID:
23633048
PMCID:
PMC3644996
DOI:
10.1038/ki.2012.468
[Indexed for MEDLINE]
Free PMC Article

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