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Opt Lett. 2013 May 1;38(9):1524-6. doi: 10.1364/OL.38.001524.

Use of hyperspectral imaging for label-free decoding and detection of biomarkers.

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Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China.


Detecting the existence of biomarkers is one of the most important issues in molecular diagnosis. This Letter presents a label-free decoding and detection method for biomarker tests based on hyperspectral imaging and interferometry. The decoding and detection results were extracted from a single hyperspectral image with different spectrum-to-thickness reconstructing algorithms, which made the testing procedure extremely fast and simple. The coding capacity of this method is more than 400, and the detection sensitivity can reach 2 ng/mm2 without fluorescent labeling.

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