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Opt Lett. 2013 May 1;38(9):1524-6. doi: 10.1364/OL.38.001524.

Use of hyperspectral imaging for label-free decoding and detection of biomarkers.

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1
Department of Biomedical Engineering, Tsinghua University School of Medicine, Beijing 100084, China.

Abstract

Detecting the existence of biomarkers is one of the most important issues in molecular diagnosis. This Letter presents a label-free decoding and detection method for biomarker tests based on hyperspectral imaging and interferometry. The decoding and detection results were extracted from a single hyperspectral image with different spectrum-to-thickness reconstructing algorithms, which made the testing procedure extremely fast and simple. The coding capacity of this method is more than 400, and the detection sensitivity can reach 2 ng/mm2 without fluorescent labeling.

PMID:
23632539
[Indexed for MEDLINE]
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