Abstract
Stimulating effect of I-ethoxy silatrane on healing of acetate derived stomach ulcer was studied in rats. The drug was shown to inhibit lipid peroxidation and free-radical oxidation in blood and gastric tissues as well as to accelerate reparation in ulcerous zone. I-Ethoxy silatrane interacted with artificial membranes and affected the respiration rate in liver mitochondria. Membranetropic effect of I-ethoxy silatrane appears to be involved in the drug ulcerostatic effect.
MeSH terms
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Animals
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Anti-Ulcer Agents*
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Bridged Bicyclo Compounds / pharmacology*
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Bridged Bicyclo Compounds / therapeutic use
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Bridged Bicyclo Compounds, Heterocyclic*
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Bridged-Ring Compounds / pharmacology*
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Cholesterol / blood
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Lipid Peroxidation / drug effects
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Mitochondria, Liver / metabolism
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Organosilicon Compounds*
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Oxygen Consumption / drug effects
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Rats
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Silicon / pharmacology*
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Silicon / therapeutic use
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Stomach Ulcer / drug therapy*
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Stomach Ulcer / metabolism
Substances
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Anti-Ulcer Agents
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Bridged Bicyclo Compounds
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Bridged Bicyclo Compounds, Heterocyclic
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Bridged-Ring Compounds
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Organosilicon Compounds
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1-ethoxysilatrane
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Cholesterol
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Silicon