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Trends Biochem Sci. 2013 Jun;38(6):312-20. doi: 10.1016/j.tibs.2013.03.005. Epub 2013 Apr 27.

Alternative cleavage and polyadenylation: the long and short of it.

Author information

1
Department of Biochemistry and Molecular Biology, New Jersey Medical School, University of Medicine and Dentistry of New Jersey, Newark, NJ 07103, USA. btian@umdnj.edu

Abstract

Cleavage and polyadenylation (C/P) of nascent transcripts is essential for maturation of the 3' ends of most eukaryotic mRNAs. Over the past three decades, biochemical studies have elucidated the machinery responsible for the seemingly simple C/P reaction. Recent genomic analyses have indicated that most eukaryotic genes have multiple cleavage and polyadenylation sites (pAs), leading to transcript isoforms with different coding potentials and/or variable 3' untranslated regions (UTRs). As such, alternative cleavage and polyadenylation (APA) is an important layer of gene regulation impacting mRNA metabolism. Here, we review our current understanding of APA and recent progress in this field.

PMID:
23632313
PMCID:
PMC3800139
DOI:
10.1016/j.tibs.2013.03.005
[Indexed for MEDLINE]
Free PMC Article

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