Format

Send to

Choose Destination
Trends Immunol. 2013 Dec;34(12):602-9. doi: 10.1016/j.it.2013.03.004. Epub 2013 Apr 27.

Immunological Genome Project and systems immunology.

Author information

1
Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.

Abstract

Immunological studies of single proteins in a single cell type have been complemented in recent years by larger studies, enabled by emerging high-throughput technologies. This trend has recently been exemplified by the discovery of gene networks controlling regulatory and effector αβ T cell subset development and human hematopoiesis. The Immunological Genome Project (ImmGen) aims to decipher the gene networks underpinning mouse hematopoiesis. The first phase, completed in 2012, profiled the transcriptome of 249 immune cell types. We discuss the utilities of the datasets in high-resolution mapping of the hematopoietic system. The immune transcriptome compendium has revealed unsuspected cell lineage relations and the network reconstruction has identified novel regulatory factors of hematopoiesis.

KEYWORDS:

hematopoiesis; systems immunology; transcriptional regulation

PMID:
23631936
PMCID:
PMC4615706
DOI:
10.1016/j.it.2013.03.004
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center