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Clin Nutr. 2014 Feb;33(1):64-8. doi: 10.1016/j.clnu.2013.04.002. Epub 2013 Apr 8.

Prevalence of and factors associated with sarcopenia in elderly patients with end-stage renal disease.

Author information

1
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
2
Department of Internal Medicine, Kangnam Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
3
Department of Internal Medicine, Chuncheon Sacred Heart Hospital, Seoul, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea.
4
Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Republic of Korea; Kidney Research Institute, Hallym University College of Medicine, Republic of Korea. Electronic address: yrisong@hanmail.net.

Abstract

BACKGROUND & AIMS:

We investigated the prevalence of sarcopenia in elderly patients with end-stage renal disease (ESRD) and its relationship with various markers of nutrition, cognitive function, depressive symptoms, inflammation and β2-microglobulin.

METHODS:

A cross-sectional study was conducted with 95 patients having ESRD aged over 50 years. Sarcopenia was defined as a decline in both muscle mass and strength.

RESULTS:

The mean age was 63.9 ± 10.0 years; 56.8% were men and 52.6% had diabetes. Sarcopenia was highly prevalent in elderly patients with ESRD (37.0% in men and 29.3% in women). Subjective Global Assessment (SGA), inflammatory markers and β2-microglobulin levels were significantly associated with sarcopenia, even after adjustment for age, gender, diabetes, and body mass index. Additionally, patients with depressive symptoms showed a higher risk of sarcopenia relative to those without depressive symptoms (odds ratio, OR = 6.87, 95% confidence interval, CI = 2.06-22.96) and sarcopenia was more likely to be present in patients with mild cognitive dysfunction (OR = 6.35, 95% CI = 1.62-34.96).

CONCLUSIONS:

Sarcopenia is highly prevalent in elderly patients with ESRD and is closely associated with SGA, inflammatory markers, β2-microglobulin, depression and cognitive dysfunction.

KEYWORDS:

Depression; End-stage renal disease; Inflammation; Sarcopenia; β2-microglobulin

PMID:
23631844
DOI:
10.1016/j.clnu.2013.04.002
[Indexed for MEDLINE]
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