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Genomics. 2013 Sep;102(3):137-9. doi: 10.1016/j.ygeno.2013.04.012. Epub 2013 Apr 28.

Translational utility of next-generation sequencing.

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1
Illumina, Inc., San Diego, CA 92122, USA.

Abstract

The development of next-generation sequencing (NGS) technology has made DNA sequencing not only rapid and cost-effective, but also highly accurate and reproducible. The translational utility of genomic sequencing is clear, from understanding of human genetic variation and its association with disease risk and individual response to treatment, to the interpretation and translation of the data for clinical decision making. It will be a critical technology for disease characterization and monitoring in molecular pathology and is expected to become a central piece of routine healthcare management which will result in accurate and reliable reporting, a prerequisite for physicians to practice genomic medicine.

KEYWORDS:

Cancer genome sequencing; Clinical sequencing; NGS; NIPT; Next-generation sequencing; Non-invasive diagnosis

PMID:
23631825
DOI:
10.1016/j.ygeno.2013.04.012
[Indexed for MEDLINE]
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