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J Infect Dis. 2013 Aug 1;208(3):500-3. doi: 10.1093/infdis/jit176. Epub 2013 Apr 22.

Histidine-rich protein 2 plasma levels predict progression to cerebral malaria in Malawian children with Plasmodium falciparum infection.

Author information

1
Department of Osteopathic Medical Specialties, Michigan State University, East Lansing, MI, USA.

Abstract

Some children with uncomplicated malaria progress to cerebral malaria despite appropriate treatment; identifying them in advance might improve their care. The objective of this study was to determine if plasma concentrations of a malaria protein, HRP2 (histidine-rich protein 2) would serve this purpose. Cases and controls were children presenting with uncomplicated malaria; the cases (n = 25) developed cerebral malaria, and the controls (n = 125) did not. Mean plasma HRP2 concentrations were significantly higher in the cases, and an HRP2 cutoff was identified that could predict disease progression (sensitivity and specificity, 88% for each). Quantitative measurements of HRP2 may be a useful screening tool.

KEYWORDS:

HRP2; cerebral malaria; malaria diagnostics

PMID:
23630364
PMCID:
PMC3699003
DOI:
10.1093/infdis/jit176
[Indexed for MEDLINE]
Free PMC Article

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