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Pediatr Blood Cancer. 2013 Oct;60(10):E122-4. doi: 10.1002/pbc.24575. Epub 2013 Apr 29.

Measles outbreak in a pediatric oncology unit and the role of ribavirin in prevention of complications and containment of the outbreak.

Author information

1
Division of Pediatric Hematology-Oncology, Department of Pediatrics, King George's Medical University, Lucknow, India.

Abstract

The role of oral ribavirin in treatment and containment of a measles outbreak in 15 children in an oncology unit is presented. Measles was diagnosed on clinical features and history of contact. Measles specific IgM ELISA and RNA were positive in 7 of 15 and 2 of 7 tested children, respectively. Duration of illness was longer in unimmunized as compared to immunized children (P = 0.02). Complications were higher in hematological malignancies (P = 0.025). Delay in starting ribavirin was associated with fatal complications (2 of 2 vs. 0 of 13, P = 0.009). Ribavirin prevented measles in all (21 of 21) patients exposed to the cases.

KEYWORDS:

measles outbreak; pediatric oncology ward; ribavirin

PMID:
23629813
DOI:
10.1002/pbc.24575
[Indexed for MEDLINE]

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