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Biomed Mater Eng. 2013;23(3):197-210. doi: 10.3233/BME-130744.

Preparation and properties of α-calcium sulphate hemihydrate and β-tricalcium phosphate bone substitute.

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Department of Orthopedics, General Hospital of People's Liberation Army, Beijing, China.


Autogenous bone graft carries the risk of complications. In contrast, artificial bone graft provides initial strength and allows new bone ingrowth. In this study, we examined methods of preparation of α-calcium sulphate hemihydrate (α-CSH) and β-tricalcium phosphate (β-TCP), and a composite of the two materials. Characterization of the materials was determined with X-ray diffraction, differential thermal analysis (DTA), scanning electron microscopy (SEM), and porosity analysis. β-TCP exhibited the spatial structure and porosity of normal bone with a macropore size of 50-400 μm and some 1 μm micropores. α-CSH exhibited a regular crystal structure. A combined material was prepared in a 1:1 weight ratio, and in a rabbit model, the rate of new bone mineralization was similar to that of autogenous bone graft. The combined material of β-TCP and α-CSH in this study may provide similar efficacy as autogenous bone graft.

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