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J Pediatr Psychol. 2013 Jul;38(6):664-74. doi: 10.1093/jpepsy/jst017. Epub 2013 Apr 28.

Social ecological predictors of longitudinal HIV treatment adherence in youth with perinatally acquired HIV.

Author information

1
Carman and Ann Adams Department of Pediatrics, Wayne State University, Detroit, MI, USA. snaarkin@med.wayne.edu

Abstract

OBJECTIVE:

To apply a social ecological model to explore the psychosocial factors prospectively associated with longitudinal adherence to antiretroviral treatment in youth perinatally infected with HIV.

METHODS:

Randomly selected youth, age 8 to <19 years old, completed cognitive testing and psychosocial questionnaires at baseline as part of a multisite protocol (N = 138). A validated caregiver-report measure of adherence was completed at baseline and 24 and 48 weeks after baseline.

RESULTS:

In multivariate analysis, youth awareness of HIV status, caregiver not fully responsible for medications, low caregiver well-being, adolescent perceptions of poor caregiver-youth relations, caregiver perceptions of low social support, and African American ethnicity were associated with nonadherence over 48 weeks.

CONCLUSIONS:

Interventions focusing on caregivers and their interactions with the individual youth and extrafamilial system should be prioritized for prevention and treatment efforts to address nonadherence during the transition into adolescents.

KEYWORDS:

HIV; antiretroviral therapy; children; patient adherence

PMID:
23629146
PMCID:
PMC3701127
DOI:
10.1093/jpepsy/jst017
[Indexed for MEDLINE]
Free PMC Article
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