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Pediatr Infect Dis J. 2013 Sep;32(9):962-4. doi: 10.1097/INF.0b013e318298dfb8.

Optimization of continuous infusion of piperacillin-tazobactam in children with fever and neutropenia.

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1
From the *Laboratoire de Bactériologie Hygiène, Institut de Microbiologie, Centre de Biologie Pathologie; †Université Lille Nord de France; ‡Hématologie Pédiatrique, Hôpital Jeanne de Flandres; §Réanimation Chirurgicale, Hôpital Claude Huriez, CHRU de Lille; and ¶Pseudomonas aeruginosa Host-pathogen Translational Research Group, Lille School of Medicine, UDSL, Lille North of France University, Lille, France.

Abstract

The study through Monte Carlo simulation of β-lactam pharmacokinetic/pharmacodynamic target attainment and determination of subsequent serum concentrations of piperacillin-tazobactam administered through continuous infusion to children treated for fever and neutropenia shows that 400 mg/kg/day has the highest probability of target attainment against Pseudomonas aeurginosa in our oncology ward compared with the standard regimen of 300 mg/kg/day.

PMID:
23629023
DOI:
10.1097/INF.0b013e318298dfb8
[Indexed for MEDLINE]
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