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Mol Psychiatry. 2014 Apr;19(4):462-70. doi: 10.1038/mp.2013.44. Epub 2013 Apr 30.

White-matter microstructure and gray-matter volumes in adolescents with subthreshold bipolar symptoms.

Author information

1
1] AP-HP, Department of Adolescent Psychopathology and Medicine, Maison de Solenn, Cochin Hospital, Paris, France [2] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [3] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [4] Université Paris-Sud 11, Orsay, France.
2
1] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [2] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [3] Université Paris-Sud 11, Orsay, France.
3
1] Université Paris Descartes, Sorbonne Paris Cité, Paris, France [2] INSERM, UMR 1000, Research unit Imaging and Psychiatry, IFR49, CEA, DSV, IBM-Service Hospitalier Frédéric Joliot, Orsay, France [3] Université Paris-Sud 11, Orsay, France [4] Psychiatry Department 91G16, Orsay Hospital, Orsay, France.
4
Institute of Psychiatry, King's College London, London, UK.
5
University of Tampere, School of Medicine, Tampere, Finland.
6
Department of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
7
Universitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
8
Department of Child and Adolescent Psychiatry, Psychosomatics and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
9
Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
10
1] Institute of Psychiatry, King's College London, London, UK [2] Department of Psychiatry, Université de Montréal, CHU Ste Justine Hospital, Montréal, QC, Canada.
11
Neurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.
12
Department of Psychiatry and Psychotherapy, Charité-Universitätsmedizin, Berlin, Germany.
13
1] Institute of Neuroscience, Trinity College Dublin, Dublin, Ireland [2] Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
14
Physikalisch-Technische Bundesanstalt (PTB), Braunschweig und Berlin, Germany.
15
School of Psychology, University of Nottingham, Nottingham, UK.
16
1] Institute of Psychiatry, King's College London, London, UK [2] MRC Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK.
17
1] School of Psychology, University of Nottingham, Nottingham, UK [2] Rotman Research Institute, University of Toronto, Toronto, ON, Canada [3] Montreal Neurological Institute, McGill University, Toronto, QC, Canada.
18
Department of Physiology and Nutritional Sciences, The Hospital for Sick Children, University of Toronto, Toronto, ON, Canada.
19
Behavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, UK.
20
1] Department of Psychiatry and Psychotherapy, Technische Universität Dresden, Dresden, Germany [2] Neuroimaging Center, Department of Psychology, Technische Universität Dresden, Dresden, Germany.

Abstract

Abnormalities in white-matter (WM) microstructure, as lower fractional anisotropy (FA), have been reported in adolescent-onset bipolar disorder and in youth at familial risk for bipolarity. We sought to determine whether healthy adolescents with subthreshold bipolar symptoms (SBP) would have early WM microstructural alterations and whether those alterations would be associated with differences in gray-matter (GM) volumes. Forty-two adolescents with three core manic symptoms and no psychiatric diagnosis, and 126 adolescents matched by age and sex, with no psychiatric diagnosis or symptoms, were identified after screening the IMAGEN database of 2223 young adolescents recruited from the general population. After image quality control, voxel-wise statistics were performed on the diffusion parameters using tract-based spatial statistics in 25 SBP adolescents and 77 controls, and on GM and WM images using voxel-based morphometry in 30 SBP adolescents and 106 controls. As compared with healthy controls, adolescents with SBP displayed lower FA values in a number of WM tracts, particularly in the corpus callosum, cingulum, bilateral superior and inferior longitudinal fasciculi, uncinate fasciculi and corticospinal tracts. Radial diffusivity was mainly higher in posterior parts of bilateral superior and inferior longitudinal fasciculi, inferior fronto-occipital fasciculi and right cingulum. As compared with controls, SBP adolescents had lower GM volume in the left anterior cingulate region. This is the first study to investigate WM microstructure and GM morphometric variations in adolescents with SBP. The widespread FA alterations in association and projection tracts, associated with GM changes in regions involved in mood disorders, suggest altered structural connectivity in those adolescents.

PMID:
23628983
PMCID:
PMC3965837
DOI:
10.1038/mp.2013.44
[Indexed for MEDLINE]
Free PMC Article

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