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Cell Adh Migr. 2013 Jul-Aug;7(4):379-87. doi: 10.4161/cam.24803. Epub 2013 Apr 29.

The actin cytoskeleton in presynaptic assembly.

Author information

1
Program in Cellular Neuroscience, Neurodegeneration and Repair; Department of Cell Biology; Yale University; New Haven, CT USA.

Abstract

Dramatic morphogenetic processes underpin nearly every step of nervous system development, from initial neuronal migration and axon guidance to synaptogenesis. Underlying this morphogenesis are dynamic rearrangements of cytoskeletal architecture. Here we discuss the roles of the actin cytoskeleton in the development of presynaptic terminals, from the elaboration of terminal arbors to the recruitment of presynaptic vesicles and active zone components. The studies discussed here underscore the importance of actin regulation at every step in neuronal circuit assembly.

KEYWORDS:

actin; active zone; synapse; synaptic adhesion; synaptic vesicle clustering; terminal arborization

PMID:
23628914
PMCID:
PMC3739815
DOI:
10.4161/cam.24803
[Indexed for MEDLINE]
Free PMC Article

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