Format

Send to

Choose Destination
Emerg Infect Dis. 2013 Apr;19(4):534-41. doi: 10.3201/eid1904.121390.

Circovirus in tissues of dogs with vasculitis and hemorrhage.

Author information

1
Blood Systems Research Institute, and Department of Laboratory Medicine, University of California, San Francisco, California, USA.

Abstract

We characterized the complete genome of a novel dog circovirus (DogCV) from the liver of a dog with severe hemorrhagic gastroenteritis, vasculitis, and granulomatous lymphadenitis. DogCV was detected by PCR in fecal samples from 19/168 (11.3%) dogs with diarrhea and 14/204 (6.9%) healthy dogs and in blood from 19/409 (3.3%) of dogs with thrombocytopenia and neutropenia, fever of unknown origin, or past tick bite. Co-infection with other canine pathogens was detected for 13/19 (68%) DogCV-positive dogs with diarrhea. DogCV capsid proteins from different dogs varied by up to 8%. In situ hybridization and transmission electron microscopy detected DogCV in the lymph nodes and spleens of 4 dogs with vascular compromise and histiocytic inflammation. The detection of a circovirus in tissues of dogs expands the known tropism of these viruses to a second mammalian host. Our results indicate that circovirus, alone or in co-infection with other pathogens, might contribute to illness and death in dogs.

KEYWORDS:

canine vascular disease; circovirus; deep sequencing; dogs; granulomatous lymphadenitis; hemorrhagic gastroenteritis; necrotizing vasculitis; vasculitis; viruses

PMID:
23628223
PMCID:
PMC3647419
DOI:
10.3201/eid1904.121390
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for CDC-NCEZID Icon for PubMed Central
Loading ...
Support Center