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Drug Alcohol Depend. 2013 Oct 1;132(3):411-3. doi: 10.1016/j.drugalcdep.2013.03.023. Epub 2013 Apr 28.

Improving the reliability and reporting of genetic association studies.

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UK Centre for Tobacco Control Studies and School of Experimental Psychology, University of Bristol, Bristol BS8 1TU, United Kingdom. Electronic address:


Genetic association studies, in particular candidate gene studies, have a long history of initially promising findings which subsequently produce a confusing mixture of replications, partial replications and non-replications. Drug and Alcohol Dependence is receiving an increasing number of submissions of genetic association studies. Here we discuss the journal's approach to considering such papers, in order to encourage credible and balanced reports which will contribute positively to the field. Recently, the STrengthening the REporting of Genetic Association studies (STREGA) initiative has provided guidelines which serve to enhance transparency. We strongly encourage authors considering submitting a genetic association study to the journal to follow these guidelines.


Candidate gene; Genetics; Genome-wide association; Replicability; STREGA

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