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Case Rep Dermatol. 2013 Mar 9;5(1):64-8. doi: 10.1159/000350182. Print 2013 Jan.

Basal cell carcinoma arising from xeroderma pigmentosum: a case report and an immunohistochemical study.

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1
Department of Dermatology, Yamato Takada Municipal Hospital, Nara.

Abstract

We describe a 26-year-old Japanese patient with basal cell carcinoma arising from xeroderma pigmentosum (XP). Immunohistochemical staining revealed dense infiltration of CD163(+) M2 macrophages, together with Foxp3(+) regulatory T cells. Interestingly, MMP9, which was reported as one of the functional markers for immunosuppressive macrophages, was also detected in the CD163(+) M2 macrophage-infiltrated areas. Our case suggests the immunological background of tumor development in a patient with XP.

KEYWORDS:

Basal cell carcinoma; CD163+; Foxp3; M2 macrophages; Xeroderma pigmentosum

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