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Front Comput Neurosci. 2013 Apr 19;7:45. doi: 10.3389/fncom.2013.00045. eCollection 2013.

Theoretical models of synaptic short term plasticity.

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School of Informatics, Institute for Adaptive and Neural Computation, University of Edinburgh Edinburgh, UK.


Short term plasticity is a highly abundant form of rapid, activity-dependent modulation of synaptic efficacy. A shared set of mechanisms can cause both depression and enhancement of the postsynaptic response at different synapses, with important consequences for information processing. Mathematical models have been extensively used to study the mechanisms and roles of short term plasticity. This review provides an overview of existing models and their biological basis, and of their main properties. Special attention will be given to slow processes such as calcium channel inactivation and the effect of activation of presynaptic autoreceptors.


mathematical model; short term plasticity; synaptic depression; synaptic facilitation; synaptic transmission

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