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Chem Commun (Camb). 2013 Jun 4;49(44):5052-4. doi: 10.1039/c3cc41254g. Epub 2013 Apr 26.

Synthesis of substituted hydantoins in low melting mixtures.

Author information

1
Department of Chemistry, Indian Institute of Technology Madras, Chennai 600036, India.

Abstract

A novel domino synthesis of 1,3,5-trisubstituted hydantoin derivatives has been developed in low melting L-(+)-tartaric acid-DMU melt mixtures. The functionalized hydantoins are obtained in good yields from β,γ-unsaturated ketoacids and urea under environmentally benign and simple reaction conditions.

PMID:
23625044
DOI:
10.1039/c3cc41254g
[Indexed for MEDLINE]

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