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Nat Rev Microbiol. 2013 Jun;11(6):400-11. doi: 10.1038/nrmicro3015. Epub 2013 Apr 29.

Interplay between viruses and host sumoylation pathways.

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  • 1MRC-University of Glasgow Centre for Virus Research, 8 Church Street, Glasgow G11 5JR, UK.


Post-translational modification by members of the small ubiquitin-like modifier (SUMO) family of proteins is important for the regulation of many cellular proteins and pathways. As obligate parasites, viruses must engage with the host cell throughout their replication cycles, and it is therefore unsurprising that there are many examples of interplay between viral proteins and the host sumoylation system. This article reviews recent advances in this field, summarizing information on sumoylated viral proteins, the varied ways in which viruses engage with SUMO-related pathways, and the consequences of these interactions for viral replication and engagement with innate and intrinsic immunity.

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