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Physiol Behav. 2013 Oct 2;122:208-15. doi: 10.1016/j.physbeh.2013.04.002. Epub 2013 Apr 23.

Sex differences and chronic stress effects on the neural circuitry underlying fear conditioning and extinction.

Author information

1
Department of Psychological & Brain Sciences, Program in Neuroscience, and Center for the Integrative Study of Animal Behavior, Indiana University, Bloomington, IN 47405, United States. Electronic address: mrfarrel@indiana.edu.

Abstract

There are sex differences in the rates of many stress-sensitive psychological disorders such as posttraumatic stress disorder (PTSD). As medial prefrontal cortex and amygdala are implicated in many of these disorders, understanding differential stress effects in these regions may shed light on the mechanisms underlying sex-dependent expression of disorders like depression and anxiety. Prefrontal cortex and amygdala are key regions in the neural circuitry underlying fear conditioning and extinction, which thus has emerged as a useful model of stress influences on the neural circuitry underlying regulation of emotional behavior. This review outlines the current literature on sex differences and stress effects on dendritic morphology within medial prefrontal cortex and basolateral amygdala. Such structural differences and/or alterations can have important effects on fear conditioning and extinction, behaviors that are mediated by the basolateral amygdala and prefrontal cortex, respectively. Given the importance of extinction-based exposure therapy as a treatment for anxiety disorders such as PTSD, understanding the neural mechanisms by which stress differentially influences fear learning and extinction in males and females is an important goal for developing sex-appropriate interventions for stress-related disorders.

KEYWORDS:

Basolateral amygdala; Dendritic morphology; Medial prefrontal cortex; Sex-dependent stress effects

PMID:
23624153
PMCID:
PMC3812406
DOI:
10.1016/j.physbeh.2013.04.002
[Indexed for MEDLINE]
Free PMC Article

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