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Fertil Steril. 2013 Aug;100(2):392-5. doi: 10.1016/j.fertnstert.2013.03.037. Epub 2013 Apr 23.

Utilization and success rates of unstimulated in vitro fertilization in the United States: an analysis of the Society for Assisted Reproductive Technology database.

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1
Dominion Fertility, Arlington, Virginia 22204, USA. johndavidgordon@mac.com

Abstract

OBJECTIVE:

To examine the utilization and outcomes of natural cycle (unstimulated) IVF as reported to the Society of Assisted Reproductive Technology (SART) in 2006 and 2007.

DESIGN:

Retrospective analysis.

SETTING:

Dataset analysis from the SART Clinical Outcome Reporting System national database.

PATIENT(S):

All patients undergoing IVF as reported to SART in 2006 and 2007.

INTERVENTION(S):

None.

MAIN OUTCOME MEASURE(S):

Utilization of unstimulated IVF; description of patient demographics; and comparison of implantation and pregnancy rates between unstimulated and stimulated IVF cycles.

RESULT(S):

During 2006 and 2007 a total of 795 unstimulated IVF cycles were initiated. Success rates were age dependent, with patients <35 years of age demonstrating clinical pregnancy rates per cycle start, retrieval, and transfer of 19.2%, 26.8%, and 35.9%, respectively. Implantation rates were statistically higher for unstimulated compared with stimulated IVF in patients who were 35 to 42 years old.

CONCLUSION(S):

Unstimulated IVF represents <1% of the total IVF cycles initiated in the United States. The pregnancy and live birth rates per initiated cycle were 19.2% and 15.2%, respectively, in patients <35 years old. The implantation rates in unstimulated IVF cycles compared favorably to stimulated IVF. Natural cycle IVF may be considered in a wide range of patients as an alternative therapy for the infertile couple.

KEYWORDS:

IVF; Natural cycle IVF; unstimulated IVF

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