Format

Send to

Choose Destination
See comment in PubMed Commons below
Curr Opin Neurobiol. 2013 Oct;23(5):841-6. doi: 10.1016/j.conb.2013.04.001. Epub 2013 Apr 23.

Sleep and synaptic changes.

Author information

1
Department of Psychiatry, University of Wisconsin, Madison, WI 53719, USA. Electronic address: ccirelli@wisc.edu.

Abstract

Several recent studies, using molecular, electrophysiological, or structural approaches, have investigated how synapses are affected by sleep, spontaneous wake, chronic sleep restriction, and acute sleep deprivation. Overall, the results have found that even a few hours of sleep or wake can modify the molecular composition of excitatory synapses, change their efficacy, and make synapses grow or shrink. Moreover, partial and total loss of sleep affect the ability of synapses to undergo long-term potentiation, an effect that may underlie some of the negative consequences of sleep deprivation on memory and other cognitive functions.

PMID:
23623392
PMCID:
PMC4552336
DOI:
10.1016/j.conb.2013.04.001
[Indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Support Center