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J AAPOS. 2013 Apr;17(2):124-8. doi: 10.1016/j.jaapos.2012.10.025.

Progression of myopia and high myopia in the Early Treatment for Retinopathy of Prematurity study: findings at 4 to 6 years of age.

Collaborators (221)

Madan A, Ball MB, Hall JY, Good WV, Good WV, Gancasz J, Durand D, Slagle T, Smith G, Shapiro M, Santiago N, Bhat R, Kaufman L, Miller M, Mittelman D, Neely D, Hynes EA, Plager D, Barr CC, Bottorff M, Whittington GK, Fishman PH, Rychwalski PJ, Gordon RA, Neff DS, Diamond JG, Gill WL, Preslan MW, Powdrill K, Hutcheson KA, Jones E, Steidl SM, Waeltermann JM, Repka MX, Shepard JA, Donahue P, Aucott SW, Collins ML, Gilmore MM, Handa JT, VanderVeen DK, Mansfield T, MacKinnon B, Cole CH, Fraioli A, Hunter D, McCabe O, Petersen R, Strominger MB, MacKinnon S, Johnson R, Tyedmers M, Cumming K, Manatrey P, Bedard MP, Casabar R, Capone A, O'Malley E, Rao R, Roarty J, Trese M, Williams G, Summers CG, Cook S, Holleschau A, Maxwell M, Christiansen SP, Brasel D, Davitt BV, Breuer L, Cruz O, Keenan W, Mantych G, Lueder G, Freedman S, Wallace D, Parkman LH, Jones SK, Enyedi L, Goldstein RF, Reynolds JD, Ziemann K, Albert GP, Awner S, Ryan R, Weber PA, Horowitz M, Behrendt C, Combs A, Dweck N, Koty R, LaGamma E, Marmor M, Flynn J, Coki O, Chiang M, Kane S, Krauss A, Lee TC, Lopez RF, Polin R, Phelps DL, Horihan C, Phillips J, Markowitz G, Merriam W, Noel LP, Tingley D, Gearinger M, Rogers GL, Bremer D, Fellows R, Klamfoth S, Arthur B, Cassady CB, Golden R, McGregor ML, Siatkowski RM, Harris C, Yazdanipanah V, Bradford RH, Leonard RE, McCaffree MA, Wheeler DT, Dolphin N, Palmer EA, Stout A, Nichols B, Epley D, Quinn GE, Koh JG, Letterio M, Abbasi S, Edmond JC, Forbes BJ, Maguire AM, Mills MD, Pierce EA, Young TL, Davidson S, Cheng K, Kelchner-Cheng J, Jones J, Bergren R, Doft B, Lobes L, Olsen K, Saunders RA, Purohit D, Stevens L, Lenhart K, Coats DK, Parker ML, Castanes M, Brown A, Edmond J, Garcia-Prats J, Holz E, Jarriel WS, Johnson K, Mandy G, Paysee EA, Rainey AM, Steinkuller PG, Yen KG, Stokes JP, Trigo Y, Gong AK, van Heuven WA, Hoffman R, Bracken S, Harrison DY, Bernstein P, King J, Teske M, Redford M, Mowery RL, Everett DF, Good WV, Quintos M, Hardy RJ, Tung B, Tsai G, Dobson V, Hargadon DD, Wood J, Quinn GE, Harvey EM, Connett J, Donovan EF, Hillis A, Holmes JM, Miller JM, Taylor CR, Good WV, Hardy RJ, Redford M, Good WV, Hardy RJ, Dobson V, Palmer EA, Phelps DL, Redford M, van Heuven WA, Barr C, Gaynon M, Shapiro M, Wallace D, Davitt BV, Fellows R, Jones J, Cumming K, Neff DS, Shepard JA, Dolphin N, Good WV, Hardy RJ, Palmer EA, Phelps DL, Quintos M, Tung B.

Author information

1
Division of Pediatric Ophthalmology, The Children's Hospital of Philadelphia and Scheie Eye Institute, University of Pennsylvania Health System, Philadelphia, Pennsylvania 19104, USA. quinn@email.chop.edu

Abstract

PURPOSE:

To report the prevalence of myopia and high myopia in children <6 years of age born preterm with birth weights <1251 g who developed high-risk prethreshold retinopathy of prematurity and who participated in the Early Treatment for Retinopathy of Prematurity trial.

METHODS:

Surviving children from the cohort of 401 participants who had developed high-risk prethreshold ROP in one or both eyes underwent cycloplegic retinoscopy at 6 and 9 months corrected age and yearly between 2 and 6 years postnatal age. Eyes were randomized to receive treatment at high-risk prethreshold ROP or conventional management with treatment only if threshold ROP developed. Myopia (spherical equivalent ≥0.25 D) or high myopia (≥5.00 D) in eyes at 4-, 5-, and 6-year examinations was reported.

RESULTS:

At ages 4, 5, and 6 years, there was no difference in the percentage of eyes with myopia (range, 64.8%-69.9%) and eyes with high myopia (range, 35.3%-39.4%) between earlier treated and conventionally managed eyes.

CONCLUSIONS:

Approximately two-thirds of eyes with high-risk prethreshold ROP during the neonatal period are likely to be myopic into the preschool and early school years. In addition, the increase in the proportion of eyes with high myopia that had been observed in both earlier-treated and conventionally managed eyes between ages 6 months and 3 years does not continue between ages 3 and 6 years.

Comment in

PMID:
23622444
PMCID:
PMC3725578
DOI:
10.1016/j.jaapos.2012.10.025
[Indexed for MEDLINE]
Free PMC Article

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