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Cell. 2013 Apr 25;153(3):507-8. doi: 10.1016/j.cell.2013.04.019.

Radical host-specific therapies for TB.

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1
Immunology Program, Sloan-Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY, USA. vanheijj@mskcc.org

Abstract

Although proinflammatory cytokines such as TNF are critical for containment of tuberculosis, they can also exacerbate disease when produced at high levels. In this issue of Cell, Roca and Ramakrishnan demonstrate that high TNF production induces reactive oxygen species in infected macrophages, ultimately leading to macrophage necrosis and bacterial dissemination.

PMID:
23622234
DOI:
10.1016/j.cell.2013.04.019
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