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J Microbiol. 2013 Jun;51(3):389-93. doi: 10.1007/s12275-013-2683-y. Epub 2013 Apr 26.

The effect of dietary intake of the acidic protein fraction of bovine colostrum on influenza A (H1N1) virus infection.

Author information

1
College of Pharmacy, Chung-Ang University, Seoul 156-756, Republic of Korea.

Abstract

Acidic protein levels in the milk decrease markedly as lactation progresses, suggesting that it is an important part of the colostrum. However, little attention has been paid to their biological function. In this study, we isolated the acidic protein fraction of bovine colostrum (AFC, isoelectric point <5) by anion-exchange chromatography, and investigated the effect of its dietary intake on influenza A (H1N1) virus infection. 100% of mice infected with 1 LD50 of the virus survived when administered AFC for 14 days prior to infection, compared with 33% survival when administered phosphate buffered saline (PBS). Moreover, consumption of AFC reduced the weight loss associated with infection. We propose that dietary intake of AFC has a prophylactic effect on influenza A virus infection.

PMID:
23620352
DOI:
10.1007/s12275-013-2683-y
[Indexed for MEDLINE]

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