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Muscle Nerve. 2013 Oct;48(4):586-8. doi: 10.1002/mus.23879. Epub 2013 Aug 30.

Magnetic resonance imaging in Duchenne muscular dystrophy: longitudinal assessment of natural history over 18 months.

Author information

1
Newcastle Magnetic Resonance Centre, Institute of Cellular Medicine, Campus for Ageing and Vitality, Newcastle University, Newcastle upon Tyne NE4 5PL, UK.

Abstract

INTRODUCTION:

In Duchenne muscular dystrophy (DMD), fat replacement of muscle may be a useful endpoint in trials of therapy, although progression in different muscle groups is uneven. In this study we assessed the progression of fat replacement with T(1) -weighted imaging over 2 9-month periods.

METHODS:

Eight ambulant, corticosteroid-treated boys with DMD were imaged at 3 Tesla at 3 time-points (baseline and 9 and 18 months) with T(1) -weighted imaging to measure fat replacement.

RESULTS:

The greatest increase in fat content was measured in the biceps femoris long head, vastus lateralis, and rectus femoris, whereas the biceps femoris short head and gluteus maximus progressed more slowly. None of the lower leg muscles studied changed significantly.

CONCLUSIONS:

MRI can measure specific changes in fat replacement of muscle over time, demonstrating the variability in rates of natural progression between muscle groups and identifying those muscles suitable for use as biomarkers in clinical trials.

KEYWORDS:

Duchenne muscular dystrophy; MRI; corticosteroids; fat replacement; longitudinal

PMID:
23620230
DOI:
10.1002/mus.23879
[Indexed for MEDLINE]
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