Format

Send to

Choose Destination
Pathog Dis. 2013 Jun;68(1):8-11. doi: 10.1111/2049-632X.12039. Epub 2013 Apr 17.

Resistance to the quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil in Pseudomonas aeruginosa clinical isolates.

Author information

1
Departamento de Bioquímica, Instituto Nacional de Cardiología, México, México. garrod13420@cardiologia.org.mx

Abstract

The quorum-quenching compounds brominated furanone C-30 and 5-fluorouracil inhibit the pathogenicity of the Pseudomonas aeruginosa laboratory strains PA01 and PA14; however, there is no report studying the effectiveness of these compounds for clinical isolates. Therefore, the effect of both quorum quenchers on the production of pyocyanin, elastase and alkaline protease of eight clinical strains from children was evaluated. Although both compounds were in general effective for the attenuation of these factors, three strains resistant to C-30 were found. For 5-fluorouracil, PA01 and some clinical isolates showed resistance for at least one phenotype.

PMID:
23620228
DOI:
10.1111/2049-632X.12039
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Silverchair Information Systems
Loading ...
Support Center