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Pathog Dis. 2013 Mar;67(2):132-5. doi: 10.1111/2049-632X.12028. Epub 2013 Feb 26.

Bordetella holmesii: initial genomic analysis of an emerging opportunist.

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1
Department of Pediatrics, Columbia University, New York, NY, USA.

Abstract

Bordetella holmesii is an emerging opportunistic pathogen that causes respiratory disease in healthy individuals and invasive infections among patients lacking splenic function. We used 16S rRNA gene analysis to confirm B. holmesii as the cause of bacteremia in a child with sickle cell disease. Semiconductor-based draft genome sequencing provided insight into B. holmesii phylogeny and potential virulence mechanisms and also identified a toluene-4-monoxygenase locus unique among bordetellae.

PMID:
23620158
PMCID:
PMC3653170
DOI:
10.1111/2049-632X.12028
[Indexed for MEDLINE]
Free PMC Article
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