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Genesis. 2013 Jul;51(7):523-8. doi: 10.1002/dvg.22398. Epub 2013 May 25.

Genomic analysis of a novel spontaneous albino C57BL/6N mouse strain.

Author information

1
The Wellcome Trust Sanger Institute, Hinxton, Cambridgeshire CB10 1SA, United Kingdom. er1@sanger.ac.uk

Abstract

We report an albino C57BL/6N mouse strain carrying a spontaneous mutation in the tyrosinase gene (C57BL/6N-Tyr(cWTSI)). Deep whole genome sequencing of founder mice revealed very little divergence from C57BL/6NJ and C57BL/6N (Taconic). This coisogenic strain will be of great utility for the International Mouse Phenotyping Consortium (IMPC), which uses the EUCOMM/KOMP targeted C57BL/6N ES cell resource, and other investigators wishing to work on a defined C57BL/6N background.

KEYWORDS:

genetics; genome sequencing; genomics; mammalian; mouse; transgenics

PMID:
23620107
PMCID:
PMC3799019
DOI:
10.1002/dvg.22398
[Indexed for MEDLINE]
Free PMC Article

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