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Lasers Surg Med. 2013 Apr;45(4):201-6. doi: 10.1002/lsm.22135.

Minimally invasive bipolar fractional radiofrequency treatment upregulates anti-senescence pathways.

Author information

1
University of California Berkeley, Berkeley, California, USA.

Abstract

BACKGROUND:

The sirtuin gene family has been implicated in various anti-senescence pathways. Its connection, if any, with the skin wound healing response has yet to be elucidated.

OBJECTIVE:

The goal of our study was to better understand the effects of FRF treatment on the sirtuin anti-senescence pathway in skin.

METHODS:

Human abdominal skin was treated with FRF, and then harvested at 0, 2, 14, and 28 days post-treatment to assess for temporal changes in gene expression levels.

RESULTS:

Decreased levels of SIRT1, 3, 5, and 7 were observed immediately post-FRF treatment. By Day 2, SIRT1, 6, and 7 expressions increased 50-100%. SIRT6 and 7 expression continued to increase through Day 28. Expression levels of apoptosis genes FoxO3 and p53 decreased, while Bax levels increased by Day 28.

CONCLUSIONS:

Our results raise the possibility that sirtuin activity may be used as an accurate corollary to clinical improvement in skin quality.

PMID:
23619899
DOI:
10.1002/lsm.22135
[Indexed for MEDLINE]

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