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Indian J Dermatol Venereol Leprol. 2013 May-Jun;79(3):291-9. doi: 10.4103/0378-6323.110753.

Role of insulin resistance and diet in acne.

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1
Department of Dermatology and STD, JIPMER, Pondicherry, India.

Abstract

There is increasing evidence in support of the interplay of growth hormone (GH), insulin, and insulin-like growth factor-1 (IGF-1) signaling during puberty, which have a causal role in pathogenesis of acne by influencing adrenal and gonadal androgen metabolism. Milk consumption and hyperglycemic diets can induce insulin and IGF-1-mediated PI3K ⁄ Akt-activation inducing sebaceous lipogenesis, sebocyte, and keratinocyte proliferation, which can aggravate acne. Occurence of acne as part of various syndromes also provides evidence in favor of correlation between IGF-1 and acne.

PMID:
23619434
DOI:
10.4103/0378-6323.110753
[Indexed for MEDLINE]
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