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Microbes Infect. 2013 Jul-Aug;15(8-9):630-9. doi: 10.1016/j.micinf.2013.04.001. Epub 2013 Apr 22.

NLRP7 and related inflammasome activating pattern recognition receptors and their function in host defense and disease.

Author information

1
Division of Rheumatology, Department of Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

Abstract

Host defense requires the maturation and release of the pro-inflammatory cytokines interleukin (IL)-1β and IL-18 and the induction of pyroptotic cell death, which depends on the activation of inflammatory Caspases within inflammasomes by innate immune cells. Several cytosolic pattern recognition receptors (PRRs) have been implicated in this process in response to infectious and sterile agonists. Here we summarize the current knowledge on inflammasome-organizing PRRs, emphasizing the recently described NLRP7, and their implications in human disease.

KEYWORDS:

AIM2-like receptor; Hydatidiform mole; Inflammasome; Inflammation; Nod-like receptor; Pattern recognition receptor

PMID:
23618810
PMCID:
PMC3722249
DOI:
10.1016/j.micinf.2013.04.001
[Indexed for MEDLINE]
Free PMC Article

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