Format

Send to

Choose Destination
See comment in PubMed Commons below
Front Pharmacol. 2013 Apr 17;4:46. doi: 10.3389/fphar.2013.00046. eCollection 2013.

Eosinophilic inflammation in allergic asthma.

Author information

1
Department of Medicine, School of Medicine, University of São Paulo São Paulo, Brazil.

Abstract

Eosinophils are circulating granulocytes involved in pathogenesis of asthma. A cascade of processes directed by Th2 cytokine producing T-cells influence the recruitment of eosinophils into the lungs. Furthermore, multiple elements including interleukin (IL)-5, IL-13, chemoattractants such as eotaxin, Clara cells, and CC chemokine receptor (CCR)3 are already directly involved in recruiting eosinophils to the lung during allergic inflammation. Once recruited, eosinophils participate in the modulation of immune response, induction of airway hyperresponsiveness and remodeling, characteristic features of asthma. Various types of promising treatments for reducing asthmatic response are related to reduction in eosinophil counts both in human and experimental models of pulmonary allergic inflammation, showing that the recruitment of these cells really plays an important role in the pathophysiology of allergic diseases such asthma.

KEYWORDS:

airway remodeling; asthma; eosinophils; experimental models of asthma; inflammation; respiratory hypersensitivity

PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Frontiers Media SA Icon for PubMed Central
    Loading ...
    Support Center