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Head Neck. 2014 Jun;36(6):782-6. doi: 10.1002/hed.23366. Epub 2013 Jul 30.

Incidence of human papillomavirus-related oropharyngeal cancer and outcomes after chemoradiation in a population of heavy smokers.

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1
Departments of Radiation Oncology and Pathology, Instituto de Investigación Hospital de la Princesa, Madrid, Spain.

Abstract

BACKGROUND:

Incidence of human papillomavirus (HPV)-related oropharyngeal carcinomas is increasing worldwide. The purpose of this study was to report the incidence in our region, and to determine the influence of HPV status on survival among a heavy smoking population.

METHODS:

p16 expression was analyzed in 102 patients with stage II to IV treated with chemoradiation. Overall survival (OS), locoregional control, and disease-free survival (DFS) were compared for HPV+ and HPV- status.

RESULTS:

The majority of patients were smokers (86%). p16 positivity was found in 26.7%. Patients who were HPV+ were younger (56 vs 59 years old; p = .052). No differences were observed regarding tumor stage, sex, or smoking between HPV+ and HPV-. Three-year OS was 67.4% for patients who were HPV+ versus 49.7% for HPV- (hazard ratio [HR], 0.55; p = .095).

CONCLUSION:

Incidence of HPV-related oropharyngeal carcinoma in Spain is similar to that reported in other European countries. In this sample of heavy smokers, we observed a nonsignificant trend for better outcomes in patients who were HPV+.

KEYWORDS:

chemoradiation; human papillomavirus; incidence; oropharyngeal cancer; smoking

PMID:
23616290
DOI:
10.1002/hed.23366
[Indexed for MEDLINE]
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