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Arch Virol. 2013 Oct;158(10):2059-68. doi: 10.1007/s00705-013-1708-5. Epub 2013 Apr 25.

Proposal for a unified norovirus nomenclature and genotyping.

Author information

1
National Institute for Public Health and the Environment, Bilthoven, The Netherlands, annelies.kroneman@rivm.nl.

Abstract

Noroviruses belong to a genus of genetically diverse viruses within the family Caliciviridae and cause acute gastroenteritis in humans and animals. They are subdivided into genogroups, each of which further segregates into genotypes. Until recently, a new genotype was based on a defined pairwise distance cutoff of complete VP1 sequences, but with the increasing number of available norovirus sequences, this cutoff is no longer accurate, and sequences in the public database have been misclassified. In this paper, we demonstrate that the pairwise distance cutoff method can no longer be used and outline a phylogenetic approach to classify noroviruses. Furthermore, we propose a dual nomenclature using both ORF1 and VP1 sequences, as recombination is common and recognizing recombinant viruses may be relevant. With the continuing emergence of new norovirus lineages, we propose to coordinate nomenclature of new norovirus genotypes through an international norovirus working group.

PMID:
23615870
PMCID:
PMC5570552
DOI:
10.1007/s00705-013-1708-5
[Indexed for MEDLINE]
Free PMC Article

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