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Mol Cell Biochem. 2013 Aug;380(1-2):107-19. doi: 10.1007/s11010-013-1664-0. Epub 2013 Apr 25.

MiR-126 suppresses colon cancer cell proliferation and invasion via inhibiting RhoA/ROCK signaling pathway.

Author information

1
Department of Gastroenterology, The Third Xiangya Hospital of Central South University, Tongzhipo Road 138#, Changsha, Hunan, People's Republic of China. linanxy3yy@csu.edu.cn

Abstract

Recent data strongly suggests the profound role of miRNAs in cancer progression. Here, we showed miR-126 expression was much lower in HCT116, SW620 and HT-29 colon cancer cells with highly metastatic potential and miR-126 downregulation was more frequent in colorectal cancers with metastasis. Restored miR-126 expression inhibited HT-29 cell growth, cell-cycle progression and invasion. Mechanically, microarray results combined with bioinformatic and experimental analysis demonstrated miR-126 exerted cancer suppressor role via inhibiting RhoA/ROCK signaling pathway. These results suggest miR-126 function as a potential tumor suppressor in colon cancer progression and miR-126/RhoA/ROCK may be a novel candidate for developing rational therapeutic strategies.

PMID:
23615712
DOI:
10.1007/s11010-013-1664-0
[Indexed for MEDLINE]

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