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Autophagy. 2013 Jul;9(7):1097-9. doi: 10.4161/auto.24634. Epub 2013 Apr 15.

The class III phosphatidylinositol 3-kinase PIK3C3/VPS34 regulates endocytosis and autophagosome-autolysosome formation in podocytes.

Author information

1
Renal Division; University Hospital Freiburg; Freiburg, Germany.

Abstract

Phosphatidylinositol phosphates are key regulators of vesicle identity, formation and trafficking. In mammalian cells, the evolutionarily conserved class III PtdIns 3-kinase PIK3C3/VPS34 is part of a large multiprotein complex that catalyzes the localized phosphorylation of phosphatidylinositol to phosphatidylinositol-3-phosphate (PtdIns3P). We demonstrate that PIK3C3 has a key function in vesicular trafficking, endocytosis and autophagosome-autolysosome formation in the highly specialized glomerular podocytes.

KEYWORDS:

Pik3c3; Vps34; autophago-lysosomal formation; autophagy; endocytosis; glomerulosclerosis; phosphoinositide 3-kinase; podocyte; proteinuria

PMID:
23614954
PMCID:
PMC3722319
DOI:
10.4161/auto.24634
[Indexed for MEDLINE]
Free PMC Article
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