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Cancer Invest. 2013 Jun;31(5):330-5. doi: 10.3109/07357907.2013.789905. Epub 2013 Apr 24.

Epidermal growth factor receptor-containing exosomes induce tumor-specific regulatory T cells.

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  • 1Department of Cardiothoracic Surgery of the Third Affiliated Hospital, Guangzhou, China.


The epidermal growth factor receptor (EGFR) has a close relation to lung cancer; its role in the pathogenesis of lung cancer is to be further elucidated. The results of this study indicate that about 80% exosomes purified from the LC biopsies contained EGFR; only about 2% exosomes contained EGFR in the samples from chronic lung inflammation. The purified exosomes induced tolerogenic DCs. Coculture of the tolerogenic DCs and Th0 cells generated the tumor antigen-specific regulatory T cells (Treg). The Tregs could suppress the tumor antigen specific CD8+ T cells.

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