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PLoS One. 2013 Apr 17;8(4):e61881. doi: 10.1371/journal.pone.0061881. Print 2013.

Childhood cancer incidence in British Indians & Whites in Leicester, 1996-2008.

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1
Cancer Epidemiology Unit, University of Oxford, Richard Doll Building, Oxford, United Kingdom.

Erratum in

  • PLoS One. 2014;9(5):e98332.

Abstract

BACKGROUND:

South Asians in England have an increased risk of childhood cancer but incidence by their individual ethnicities using self-assigned ethnicity is unknown. Our objective was to compare the incidence of childhood cancer in British Indians and Whites in Leicester, which has virtually complete, self-assigned, ethnicity data and the largest population of Indians in England.

METHODS:

We obtained data on all cancer registrations from 1996 to 2008 for Leicester with ethnicity obtained by linkage to the Hospital Episodes Statistics database. Age-standardised incidence rates were calculated for childhood cancers in Indians and Whites as well as rate ratios, adjusted for age.

RESULTS:

There were 33 cancers registered among Indian children and 39 among White children. The incidence rate for Indians was greater compared to Whites for all cancers combined (RR 1.82 (95% CI 1.14 to 2.89); p = 0.01), with some evidence of increased risk of leukaemia (RR 2.20 (0.95 to 5.07); p = 0.07), lymphoma (RR 3.96 (0.99 to 15.84); p = 0.04) and central nervous system tumours (RR 2.70 (1.00 to 7.26); p = 0.05). Rates were also higher in British Indian children compared to children in India.

CONCLUSIONS:

British Indian children in Leicester had an increased risk of developing cancer compared to White children, largely due to a higher incidence of central nervous system and haematological malignancies.

PMID:
23613964
PMCID:
PMC3629092
DOI:
10.1371/journal.pone.0061881
[Indexed for MEDLINE]
Free PMC Article
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