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Genomics Inform. 2013 Mar;11(1):38-45. doi: 10.5808/GI.2013.11.1.38. Epub 2013 Mar 31.

Annotation of genes having candidate somatic mutations in acute myeloid leukemia with whole-exome sequencing using concept lattice analysis.

Author information

  • 1Division of Biomedical Informatics, Seoul National University Biomedical Informatics (SNUBI) and Systems Biomedical Informatics National Core Research Center, Seoul National University College of Medicine, Seoul 110-799, Korea.

Abstract

In cancer genome studies, the annotation of newly detected oncogene/tumor suppressor gene candidates is a challenging process. We propose using concept lattice analysis for the annotation and interpretation of genes having candidate somatic mutations in whole-exome sequencing in acute myeloid leukemia (AML). We selected 45 highly mutated genes with whole-exome sequencing in 10 normal matched samples of the AML-M2 subtype. To evaluate these genes, we performed concept lattice analysis and annotated these genes with existing knowledge databases.

KEYWORDS:

DNA mutational analysis; DNA sequence analysis; acute myeloid leukemia; biolattice; concept lattice analysis; oncogenes

PMID:
23613681
PMCID:
PMC3630384
DOI:
10.5808/GI.2013.11.1.38
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