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J Matern Fetal Neonatal Med. 2013 Nov;26(17):1749-52. doi: 10.3109/14767058.2013.798291. Epub 2013 May 24.

Can we reduce the surgical site infection rate in cesarean sections using a chlorhexidine-based antisepsis protocol?

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Department of Obstetrics and Gynecology, Lis Maternity Hospital, Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel-Aviv University , Tel-Aviv , Israel and.



To determine whether chlorhexidine-based antisepsis reduces the rate of surgical site infections (SSIs) in elective and non-elective cesarean sections (CS) compared with povidone-iodine protocol.


This was a retrospective study. Women undergoing elective and non-elective CS during two periods of time who were treated with two different antisepsis protocols were included. The protocols for antisepsis were povidone-iodine 10% scrub followed by 10% povidone-iodine in 65% alcohol (n = 163) and chlorhexidine 2% followed by 70% alcohol (n = 163). The rate of SSIs and the risk factors for their occurrence were calculated and compared between the two groups.


Antisepsis with chlorhexidine and alcohol was associated with a lower rate of SSIs, 10.43% versus 3.07% with povidone-iodine (p = 0.08). The two groups of patients were similar in baseline characteristics. Risk factors associated with SSIs were body mass index, urgent CS, and the use of the povidone-iodine protocol.


Antisepsis with Chlorhexidine-based regimen was associated with a significant reduction in the rate of SSIs compared to povidone-iodine antisepsis in women undergoing elective and non-elective CS. This is of extreme clinical importance, as a change in antisepsis protocol can significantly reduce the morbidity and healthcare costs regarding cesarean sections.

[Indexed for MEDLINE]

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