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Adv Immunol. 2013;117:99-125. doi: 10.1016/B978-0-12-410524-9.00004-9.

Intracellular pathogen detection by RIG-I-like receptors.

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Harvard Medical School and Division of Gastroenterology, Boston Children's Hospital, Boston, MA, USA.


The RIG-I-like receptors (RLRs) RIG-I, MDA5, and LGP2 trigger innate immune responses against viral infections that serve to limit virus replication and to stimulate adaptive immunity. RLRs are cytosolic sensors for virus-derived RNA and thus responsible for intracellular immune surveillance against infection. RLR signaling requires the adapter protein MAVS to induce type I interferon, interferon-stimulated genes, and proinflammatory cytokines. This review focuses on the molecular and cell biological requirements for RLR signal transduction.

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