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Int J Nanomedicine. 2013;8:1377-83. doi: 10.2147/IJN.S37788. Epub 2013 Apr 12.

Glycyrrhizic acid nanoparticles inhibit LPS-induced inflammatory mediators in 264.7 mouse macrophages compared with unprocessed glycyrrhizic acid.

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1
Key Laboratory of Forest Plant Ecology, Northeast Forestry University, Harbin, People's Republic of China.

Abstract

Glycyrrhizic acid (GA), the main component of radix glycyrrhizae, has a variety of pharmacological activities. In the present study, suspensions of GA nanoparticles with the average particle size about 200 nm were prepared by a supercritical antisolvent (SAS) process. Comparative studies were undertaken using lipopolysaccardide (LPS)-stimulated mouse macrophages RAW 264.7 as in vitro inflammatory model. Several important inflammation mediators such as NO, PGE2, TNF-α and IL-6 were examined. These markers were highly stimulated by LPS and were inhibited both by nano-GA and unprocessed GA in a dose-dependent manner, especially PGE2 and TNF-α. However nano-GA and unprocessed GA inhibited NO only at a high concentration. In general, we found that GA nanoparticle suspensions exhibited much better anti-inflammatory activities compared to unprocessed GA.

KEYWORDS:

glycyrrhizic acid; inflammatory cytokines; mouse macrophages RAW 264.7; nanoparticle

PMID:
23610519
PMCID:
PMC3629880
DOI:
10.2147/IJN.S37788
[Indexed for MEDLINE]
Free PMC Article
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